The 2019 community meeting is hosted by the Clinical Bioinformatics Area, FPS, Hospital Virgen del Rocío.
We are glad to announce the 4th Disease Maps Community Meeting (DMCM2019) that will take place 2nd - 4th October in Hospital Virgen del Rocio, Sevilla, Spain.
The event is held on yearly basis and presents advances in our knowledge on the molecular mechanisms of diseases, in mathematical modelling for understanding their progression and in developing software for supporting maps and carrying out different types of analyses. The meeting includes not only presentations and posters but also software demos and discussions on hot topics in systems medicine. Please see, for example, the outcome of the Luxembourg meeting discussions recently published in Briefings in Bioinformatics.
The booklet is available here
Photos from the meeting are available at #DMCM2019 Twitter Pictures
Key dates
Abstract submission deadline: 21st July 2019 (extended)
Decision on abstract selection: 15th August 2019
Registration deadline: 15th September 2019
DMCM2019: 2nd - 4th October 2019
Invited speakers
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Inge Jonassen, PhD, University of Bergen. Norway Dr. Jonassen is a Full Professor at the department of Informatics at the University of Bergen. He is also the head of the Computational Biology Unit at the same university and the head of the Norwegian Node of ELIXIR, the European infrastructure for bioinformatics. His research focuses on development and advanced application of methods for analysis of omics data and discovery of patterns in molecular biological data. He is associated with the CCBIO Centre for Cancer Biomarkers in Bergen and also with the NeuroSysMed research centre for clinical treatment in neurodegenerative diseases. More information: Jonassen Group. |
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Julio Saez-Rodriguez, PhD, RWTH-Aachen University, Germany Julio Saez-Rodriguez is Professor of Medical Bioinformatics and Data Analysis at the Faculty of Medicine of Heidelberg University. Julio is a member of the Disease Maps team and participates in the development of the Multiple Sclerosis Map. Julio's research interests are in computational methods and tools for studying information transfer within signalling networks, and applications to disease-related questions, with a focus on cancer and fibrosis. More information can be found at http://saezlab.org. |
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Jonathan Karr, PhD, Icahn School of Medicine at Mount Sinai, USA Jonathan Karr is a Fellow at the Icahn School of Medicine at Mount Sinai in New York. The goal of Jonathan's research group is to develop mechanistic whole-cell computational models that predict the behavior of individual cells by representing all of the biochemical activity in cells. Jonathan earned his PhD in Biophysics and his MS in Medicine from Stanford University and his SB in Physics and SB in Brain & Cognitive Sciences from MIT. See his research group's website for more information: https://www.karrlab.org. |
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Sampsa Hautaniemi, PhD, University of Helsinki, Finland Sampsa Hautaniemi is a Professor of Systems Biology and the Director of Systems Oncology research program at the Faculty of Medicine of the University of Helsinki. His research focuses on developing and applying machine learning methods to understanding and overcoming drug resistance in cancers. More information can be found at the Hautaniemi lab. |
Programme
Wednesday 2nd October
| 09:00 Disease Maps Members/Coordinators Meeting |
10:30 Coffee Break
Session 1: Using existing data to create disease maps
| 11:00 Welcome Joaquin Dopazo, Clinical Bioinformatics Area, FPS, Sevilla, Spain |
| 11:10 Opening Key Lecture 1 Analysis of multi-omics data to improve the understanding of Parkinson’s disease Inge Jonassen, University of Bergen, Norway |
| 12:10 Short talks Towards automatic assembly and management of evolving disease models: modularisation, merging, layout, comparison and versioning Alexander Mazein, University of Luxembourg, Luxembourg Common disease mechanisms at play? A modelling challenge Rudi Balling, University of Luxembourg, LCSB, Luxembourg Disease map for aHUS – molecular mechanisms and hypotheses Tatiana Serebriyskaya, RacursBioMed Ltd., Russia A disease map and a database for cystic fibrosis Catarina Pereira, University of Lisboa Faculty of Sciences, BioISI – Biosystems and Integrative Science Institute, Lisboa, Portugal |
| 14:00 Lunch and Poster viewing |
Session 2: Computational models
| 15:30 Key Lecture 2 Toward whole-cell computational models for precision medicine Jonathan Karr, Icahn School of Medicine at Mount Sinai, New York, USA |
| 16:30 Short talks A multiscale modelling platform to simulate drug synergies in different cell population architectures. Miguel Ponce de Leon, Barcelona Supercomputing Center, Barcelona, Spain Executable Disease Maps – Addressing the challenges of large scale dynamical modelling Anna Niarakis, GenHotel, University of Evry, Paris-Saclay, France Generation of process diagrams for computational modelling: lessons from the classroom Tom C. Freeman, The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK |
Thursday 3rd October
Session 3: Multi-view data integration
| 9:00 Key Lecture: Logic modelling to integrate disease maps and various omics data Julio Saez-Rodriguez, RWTH-Aachen University Hospital, Aachen, Germany |
| 10:00 Highlighted talk Elixir Sponsor talk |
10:30 Coffee break and poster viewing
| 11:00 Selected short talks Atlas of Cancer Signaling Network: a resource of multi-scale biological maps to study disease mechanisms Luis Cristobal Monraz Gomez, Institut Curie, France Interactive visualization of phenotypic and genotypic information in disease maps for identification of mechanistic biomarkers Sascha Herzinger, University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Luxembourg Reactome Pathway Analysis and Visualization Henning Hermjakob, EMBL-EBI, United Kingdom |
| 12:30 Poster session Flash presentations |
13:30 Lunch and poster viewing
Session 4: Discussions
| 15:00 Introduction |
| 15:30 Discussion topics Four discussion sessions (Topics to be determined) |
| 17:30 Presentation preparation and final discussion |
| 18:30 Results presentation |
| 20:30 Gala Dinner |
Friday 4th October
Session 5: Clinical application of disease maps
| 09:00 Key Lecture 4 Computational approaches to tackle chemoresistance in high-grade serous ovarian cancer Sampsa Hautaniemi, Faculty of Medicine, University of Helsinki, Finland |
| 10:00 The DisGeNET platform’s 10 anniversary Developing a knowledge base for disease genomics Janet Piñero, GRIB (IMIM-UPF), Spain |
10:30 Coffee break
| 11:00 Short talks Machine learning and mechanistic models for drug repositioning in rare diseases Marina Esteban-Medina, Clinical Bioinformatics Area, FPS, Sevilla, Spain Connecting metabolic biomarkers with biological pathways and clinical data to enable omics data interpretation Denise N. Slenter, Maastricht University, Netherlands Conciliation of medicine systems disease maps and other molecular interaction networks using logical properties of ontology Vincent Henry, Inria/ICM, Paris, France Different layout aware formats in systems biology used by Minerva platform Piotr Gawron, University of Luxembourg, Luxembourg |
13:00 Poster viewing
13:30 Lunch
Hands-on session
Tutorials of the following tools and resources
| 14:30 BiNoM, ACSN |
| 14:30 MINERVA |
| 15:30 Hipathia |
NaviCell tutorial materials (zip)
(Depending on computers and rooms available, will be distributed in one or two parallel hands-on sessions)
17:00h Meeting closure
Abstract submission
Please submit an abstract (up to 400 words) via the submission link for an oral presentation and/or a poster.
Abstract submission deadline: 21st July 2019 (extended).
Registration
The registration is free but mandatory. Please fill in the registration form.
Registration deadline: 15th September 2019.
Location
Edificio de Gobierno, Hospital Universitario Virgen del Rocío
Avenida Manuel Siurot s/n, 41013 Seville, Spain
Accommodation
Recommended hotels:
AC Hotel Ciudad de Sevilla, a Marriott Lifestyle Hotel
AV Manuel Siurot 25, 41013 Seville, Spain
Tel. +34 954 230 505
Silken Al-Andalus Palace
Avenida de la Palmera s/n, esq. C/ Paraná, 41012 Seville, Spain
Tel. +34 954 230 600
EXE Sevilla Palmera
Cardenal Ilundain, 28, 41013 Seville, Spain
Tel. +34 932 087 108
(5 minutes walk from the event)
Melia Sevilla
Dr. Pedro de Castro, 1, 41004 Seville, Spain
Tel. +34 912 764 747
Organisers
Local organisers
Clinical Bioinformatics Area Group
Joaquin Dopazo
Rubén García Serrano
Maria Peña Chilet
Disease Maps Project Coordinators
Alexander Mazein
Marek Ostaszewski
Inna Kuperstein
Anna Niarakis
Andrei Zinovyev
Reinhard Schneider
Emmanuel Barillot
Rudi Balling
Charles Auffray
Contact
If you have any questions, please contact Inmaculada Guillén at the technical secretariat of the CBA group and the Disease Maps Organisers.
Co-organizers
The Spanish National Bioinformatics Institute (INB) is the ISCIII Bioinformatics platform. Its Coordination Node is supported by grant PT17/0009/0001, of the Acción Estratégica en Salud 2013-2016 of the Programa Estatal de Investigación Orientada a los Retos de la Sociedad, funded by the Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (ERDF).