About

The Disease Maps Project as a large-scale community effort to apply systems biomedicine paradigms in building knowledge repositories, mapping omics data on molecular mechanisms, and simulation of their perturbations for effect prediction.

Our international and interdisciplinary community grows since 2015, fueled by exchanges during annual meetings, regular virtual meetings, and over a dedicated Slack channel. We collaborate closely with the communities of the systems biology neighbourhood, including SBML, SBGN, and ELIXIR Systems Biology Communities, and Reactome and WikiPathways databases.

Get involved

Contact us! We are actively expanding the list of areas covered by the Disease Maps Project and are looking for new contributors interested in molecular mechanisms of physiology and diseases: computational biologists, clinicians or experimental biologists. If you are working on one of the projects which are already listed on this website, we would be happy to collaborate.

Project Leaders

Project leaders develop and refine the concept of disease maps, coordinate the activities of the community effort, help to initiate new maps, advise on best practices and offer guidelines.

Alexander Mazein Researcher, Luxembourg Institute of Health, Luxembourg	Anna Niarakis Professor, University of Toulouse III - Paul Sabatier, Toulouse, France	Laurence Calzone Researcher, Institut Curie, Paris, France
Luiz Ladeira Researcher, University of Liège, Liège, Belgium	Marek Ostaszewski Researcher, University of Luxembourg, Belvaux, Luxembourg	Marc Gillespie Professor, St. John's University, New York, US
Martina Kutmon Associate professor, Maastricht University, Maastricht, Netherlands	Matti Hoch Researcher, University of Rostock, Rostock, Germany	Shailendra Gupta Researcher, University of Rostock, Rostock, Germany

Principal Investigators

Principal investigators support and advise the Community.

Emma Schymanski, PhD Head of Environmental Cheminformatics group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg	Emmanuel Barillot, PhD Director of the U900 Institut Curie/INSERM/Ecole des Mines ParisTech, Paris, France	Liesbet Geris, PhD Head of the Biomechanics Research Unit, University of Liège and KU Leuven, Belgium. Executive Director of the Virtual Physiological Human Society
Olaf Wolkenhauer, PhD Head of the Department of Systems Biology & Bioinformatics, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany	Venkata Satagopam, PhD Head of Clinical and Translational Informatics group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg

Founding members

We would like to thank our founding mebers for their longstanding and enthusiastic support to the concept of disease maps.

Andrei Zinovyev Institut Curie, Paris, France	Charles Auffray European Institute for Systems Biology and Medicine, Lyon, France	Inna Kuperstein Institut Curie, Paris, France
Reinhard Schneider, PhD Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg	Rudi Balling Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg

Acknowledgements

Many published disease maps were developed in collaboration with the Systems Biology Institute, Tokyo, Japan (Mizuno et al., 2012, PMID 22647208; Matsuoka et al., 2013, PMID 24088197; Fujita et al., 2014, PMID 23832570; Kuperstein et al., 2015, PMID 26192618). We would like to underline the role of Prof. Hiroaki Kitano in pioneering the process description representation of signalling networks and initiating first comprehensive disease-relevant extensive reconstructions of signalling pathways (Oda et al., 2005, PMID 16729045; Oda and Kitano, 2006, PMID 16738560; Caron et al., 2010, PMID 21179025).