Projects

   Disease maps for specific diseases
   Cross-disease projects
   Adverse outcome maps for immunotoxicology

The Disease Maps Community consolidates efforts focused on describing disease mechanisms. We aim to progress together through advancing technological solutions, sharing resources and best practices. New contributors are very welcome: please propose a new disease map or join one of the existing projects. Project progress status:

☆☆☆☆☆ Initiated/funded ★☆☆☆☆ Active development ★★☆☆☆ Available for exploration online

★★★☆☆ Published ★★★★☆ Maintained and improved ★★★★★ Applications demonstrated

Disease maps for specific diseases

This section lists projects focused on specific diseases. The list is organised according to the progress status of the projects.

COVID-19, Parkinson’s disease, cancer, rheumatoid arthritis, asthma, sarcopenia, cystic fibrosis, heart failure, atherosclerosis, osteoarthritis, Sjogren’s syndrome, diabetic kidney disease, atopic dermatitis, psoriasis, liver steatosis, cholestasis

COVID-19 ★★★★★	Resource: COVID-19 Disease Map Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Parkinson's disease ★★★★★	Resource: Parkinson's Disease Map Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Cancer ★★★★★	Resource: Atlas of Cancer Signalling Network Contact: Inna Kuperstein, Institut Curie, Paris, France Publications: PubMed
Rheumatoid arthritis ★★★★★	Resource: Rheumatoid Arthritis Map Contact: Anna Niarakis, Paul Sabatier University - Toulouse III, Toulouse, France Publications: DOI
Asthma ★★★☆☆	Resource: AsthmaMap Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Sarcopenia ★★★☆☆	Resource: Sarcopenia Map Contact: Matti Hoch, University of Rostock, Rostock, Germany Publications: PubMed
Cystic fibrosis ★★★☆☆	Resource: CyFi-MAP Contact: Catarina Pereira, University of Lisbon, Lisbon, Portugal Publications: PubMed
Heart failure ★★★☆☆	Resource: CardioMap Contact: Nikolaus Berndt, Charité – Universitätsmedizin Berlin; Irina Balaur, University of Luxembourg | Publications: PubMed
Atherosclerosis ★☆★☆★	Resource: Atherosclerosis Map Contact: Steven Watterson, Ulster University, Derry, Northern Ireland, UK Publications: PubMed | Model: BioModels
Liver steatosis ★★★☆☆	Resource: Liver Lipid Metabolism Physiological Map Contact: Luiz Ladeira, University of Liège, Liège, Belgium Publications: PubMed
Cholestasis ★★★☆☆	Resource: Liver Bile Secretion Physiological Map Contact: Luiz Ladeira, University of Liège, Liège, Belgium Publications: PubMed
Osteoarthritis ★★☆☆☆	Resource: KneePainMap Contact: Bernd Seilheimer, Heel GmbH, Germany
Blood pressure ★★☆☆☆	Resource: Atlas of blood pressure Contact: Ahmad Vaez, University of Groningen, Groningen, The Netherlands
Sjogren's syndrome ★☆☆☆☆	Resource: Sjogren Map Contact: Sacha E Silva-Saffar, University of Evry, University of Paris-Saclay, France
Diabetic kidney disease ★☆☆☆☆	Resource: Diabetic Kidney Disease Map Contact: Farnoush Kiyanpour, Isfahan University of Medical Sciences, Iran
Pseudomonas aeruginosa infection ★☆☆☆☆	Resource: Pseudomonas aeruginosa Infection Disease Map Contact: Francesco Messina, National Institute of Infectious Diseases Lazzaro Spallanzani, Rome, Italy

Cross-disease projects

This section includes projects that focus on shared mechanisms of two or more diseases, interactions between two or more diseases, or broader aspects applicable to many diseases.

Acute inflammation ★★★★★	Resource: Atlas of Inflammation Resolution Contact: Matti Hoch, University of Rostock, Rostock, Germany Publications: PubMed
Neural tube closure ★★★★☆	Resource: Neural Tube Closure Physiological Map Contact: Alessio Gamba, University of Liège, Liège, Belgium Publications: PubMed
Chronic inflammation ★★★★★	Resource: SYSCID Map Diseases: IBD, rheumatoid arthritis and systemic lupus erythematosus Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Inflammatory skin diseases ★★★★★	Resource: Inflammatory Skin Diseases Map Diseases: psoriasis, atopic dermatitis Contact: Marcio Acencio, Oxana Lopata and Marek Ostaszewski, University of Luxembourg, Luxembourg
Ulcerative colitis and atopic dermatitis ★★★★★	Resource: Map of ulcerative colitis and atopic dermatitis Diseases: ulcerative colitis, atopic dermatitis Contact: Oxana Lopata, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Kidney crystallography and tubular necrosis ★☆☆☆☆	Resource: Nephron Physiological Map Diseases: kidney crystallopathy, tubular necrosis Contact: Alessio Gamba, University of Liège, Liège, Belgium
Cognitive function defects ★☆☆☆☆	Resource: Brain Development Physiological Map Contact: Luiz Ladeira, University of Liège, Liège, Belgium
Immune system development ★☆☆☆☆	Resource: Human Immune System Development Map (HIDmap) Contact: Christiane Spruck, IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany

Adverse outcome maps for immunotoxicology

This section includes maps that describe mechanisms of adverse effects of various treatments and are based on the adverse outcome pathway (AOP) concept in toxicology.

CAR T cell therapy ★★★☆☆	Resource: CAR T cell AOP Map Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Cytokine release syndrome ★★★☆☆	Resource: Cytokine Release Syndrome Map Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
IL2-induced hepatotoxicity ★★☆☆☆	Resource: IL2-induced Hepatotoxicity Map Diseases: cancer, autoimmune diseases Contact: Oxana Lopata, University of Luxembourg, Belvaux, Luxembourg
Fine and ultrafine particle toxicity ★★☆☆☆	Resource: ExposomeMap-PM Contact: Petr Nazarov, Luxembourg Institute of Health, Luxembourg