ABOUT

PROJECTS

EVENTS

GUIDELINES

TOOLS

RELATED EFFORTS

PUBLICATIONS

HOW TO CITE

CONTACT

Projects

   Disease maps for specific diseases
   Cross-disease projects
   Adverse outcome maps for immunotoxicology

The Disease Maps Community consolidates efforts focused on describing disease mechanisms. We aim to progress together through advancing technological solutions, sharing resources and best practices. New contributors are very welcome: please propose a new disease map or join one of the existing projects. Project progress status:

☆☆☆☆☆ Initiated/funded
★☆☆☆☆ Active development
★★☆☆☆ Available for exploration online
★★★☆☆ Published
★★★★☆ Maintained and improved
★★★★★ Applications demonstrated

Disease maps for specific diseases

This section lists projects focused on specific diseases. The list is organised according to the progress status of the projects.

COVID-19, Parkinson’s disease, cancer, rheumatoid arthritis, asthma, sarcopenia, cystic fibrosis, heart failure, atherosclerosis, osteoarthritis, Sjogren’s syndrome, diabetic kidney disease, atopic dermatitis, psoriasis, liver steatosis, cholestasis

COVID-19 Resource: COVID-19 Disease Map
Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg
Publications: PubMed
Parkinson's disease Resource: Parkinson's Disease Map
Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg
Publications: PubMed
Cancer Resource: Atlas of Cancer Signalling Network
Contact: Inna Kuperstein, Institut Curie, Paris, France
Publications: PubMed
Rheumatoid arthritis Resource: Rheumatoid Arthritis Map
Contact: Anna Niarakis, Paul Sabatier University - Toulouse III, Toulouse, France
Publications: DOI
Asthma Resource: AsthmaMap
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg
Publications: PubMed
Sarcopenia Resource: Sarcopenia Map
Contact: Matti Hoch, University of Rostock, Rostock, Germany
Publications: PubMed
Cystic fibrosis Resource: CyFi-MAP
Contact: Catarina Pereira, University of Lisbon, Lisbon, Portugal
Publications: PubMed
Heart failure Resource: CardioMap
Contact: Nikolaus Berndt, Charité – Universitätsmedizin Berlin; Irina Balaur, University of Luxembourg | Publications: PubMed
Atherosclerosis Resource: Atherosclerosis Map
Contact: Steven Watterson, Ulster University, Derry, Northern Ireland, UK
Publications: PubMed | Model: BioModels
steatosis Resource: Liver Lipid Metabolism Physiological Map
Contact: Luiz Ladeira, University of Liège, Liège, Belgium
Publications: Preprint
cholestasis Resource: Liver Bile Secretion Physiological Map
Contact: Luiz Ladeira, University of Liège, Liège, Belgium
Publications: Preprint
Osteoarthritis Resource: KneePainMap
Contact: Bernd Seilheimer, Heel GmbH, Germany

sjogrens Resource: Sjogren Map
Contact: Sacha E Silva-Saffar, University of Evry, University of Paris-Saclay, France

diabetickidneydisease Resource: Diabetic Kidney Disease Map
Contact: Farnoush Kiyanpour, Isfahan University of Medical Sciences, Iran

atopicdermatitis Resource: Atopic Dermatitis Map
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

psoriasis Resource: Psoriasis Map
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

Cross-disease projects

This section includes projects that focus on shared mechanisms of two or more diseases, interactions between two or more diseases, or broader aspects applicable to many diseases.

Acute inflammation Resource: Atlas of Inflammation Resolution
Contact: Matti Hoch, University of Rostock, Rostock, Germany
Publications: PubMed
Neural tube closure Resource: Neural Tube Closure Physiological Map
Contact: Alessio Gamba, University of Liège, Liège, Belgium
Publications: PubMed
syscid Resource: SYSCID Map
Diseases: IBD, rheumatoid arthritis and systemic lupus erythematosus
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg
Publications: DOI
immuniverse Resource: ImmUniverse Map
Diseases: ulcerative colitis, atopic dermatitis
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg
nephron Resource: Nephron Physiological Map
Diseases: kidney crystallopathy, tubular necrosis
Contact: Alessio Gamba, University of Liège, Liège, Belgium
braindevelopment Resource: Brain Development Physiological Map
Contact: Luiz Ladeira, University of Liège, Liège, Belgium
immunedev Resource: Human Immune System Development Map (HIDmap)
Contact: Christiane Spruck, IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany

Adverse outcome maps for immunotoxicology

This section includes maps that describe mechanisms of adverse effects of various treatments and are based on the adverse outcome pathway (AOP) concept in toxicology.

cart Resource: CAR T cell AOP Map
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg
Publications: Preprint
CRS Resource: Cytokine Release Syndrome Map
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg