Disease maps and irAOPs in the immune system effects of immunomodulatory therapies

Kristin Reiche, Fraunhofer Institute for Cell Therapy and Immunology IZI, Department of Diagnostics, Germany

The EU funded project imSAVAR (Immune safety avatar: Nonclinical mimicking of the immune system effects of immunomodulatory therapies) develops a platform to improve the prediction of potential side effects and thereby the safety and efficacy of immunomodulatory therapeutics. imSAVAR utilizes irAOPs (immune-related adverse outcome pathways) to describe the sequential order of key events, test systems as well as related molecules that result in an immune-related adverse outcome. In the symposium we give an overview of imSAVAR’s guidelines and methods to use Disease Maps as a computational knowledge repository of irAOPs, and provide insights in identified challenges and possible solutions of thereof. We will discuss possible systems biomedicine approaches to advance the computataional use of irAOPs.

Programme

• Kristin Reiche: The Mission of imSAVAR – pathways towards improved nonclinical mimicking of the immune system effects of immunomodulatory therapies (10 min)

• Katherina Sewald: Introduction of irAOPs into biomedical research (20 min)

• Miriam Alb and Christina Sakellariou: imSAVARs journey towards a harmonized Cytokine Release Syndrome irAOP (20min)

• Marek Ostaszewski: Construction, visual exploration and analytics of irAOP systems biology diagrams (10 min)

• Patricia Gogesh: Title: Using an irAOP as tool for analyzing mechanisms behind vascular leakage

• Working meeting with representatives of the EDITH consortium