Hypertension
Atlas of Blood Pressure Physiology Map (BPMap)
Development status: Active development
Sustainable support: MINERVA Platform
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Construction tool: CellDesigner
Contact: Ahmad Vaez, Department of Epidemiology, University of Groningen, Groningen, The Netherlands (a.vaez (at) umcg.nl)
Description
Atlas of Blood Pressure Physiology Map (BPMap) is a bioinformatics resource for advancing translational medicine and enhancing our understanding of the pathophysiology of hypertension. By focusing on signaling, gene regulatory, and metabolic pathways, the BPMap provides critical insights into the mechanisms underlying hypertension. Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases, and it remains the leading cause of premature death worldwide. An estimated 1.28 billion adults aged 30–79 years across the globe suffer from hypertension. To reduce premature mortality from cardiovascular diseases, preventing and controlling hypertension is a vital public health strategy. Despite its high prevalence and significant health impact, many aspects of the underlying pathological mechanisms of high blood pressure remain unclear. This knowledge gap results in insufficient preventive and therapeutic strategies. The BPMap aims to deepen our understanding of the pathogenesis of hypertension. By providing visual representations of biological processes, it allows clinical and life sciences researchers to closely inspect disease mechanisms. Additionally, the computer-tractable representation of these processes enables bioinformaticians to build mathematical models of disease mechanisms. By unraveling the complex interplay of key factors, the AHMDM paves the way for more precisely targeted therapeutic options, leading to better global health outcomes and fewer side effects.
The Team
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Babak Babaabasi, M.Sc Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran Biologist, PhD Student Development of the AHMDM |
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Mohamadreza Sehhati, PhD Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran Associate professor Development of the AHMDM |
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Harold Snieder, PhD Department of Epidemiology, University of Groningen, Groningen, The Netherlands Professor of Genetic Epidemiology Review |
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Ahmad Vaez, MD, PhD Department of Epidemiology, University of Groningen, Groningen, The Netherlands Senior Researcher Supervision and review |
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Marek Ostaszewski, PhD LCSB, University of Luxembourg, Luxembourg Senior Researcher Review and support |
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Ahmed Hemedan, PhD LCSB, University of Luxembourg, Luxembourg Postdoctoral Researcher Review and support |
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Anna Niarakis, PhD University of Toulouse, France Professor Review and support |