Cholestasis

Liver Bile Secretion Physiological Map

Home Page: ONTOX Physiological Maps website
Online access and exploration: https://ontox.elixir-luxembourg.org/minerva/
Development status: First version is complete and a preprint is available
Umbrella project: ONTOX project
Disease IDs: D002779, DOID:13580, HP:0001396
Synonyms: Bile duct obstruction, biliary stasis
Sustainable support: Biomechanics Research Unit, MINERVA Platform
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Publication: Preprint
Construction tool: CellDesigner
Funding: EU Horizon 2020 ONTOX project (grant agreement No 963845).
Contact: Luiz Ladeira, University of Liège, lcladeira(at)uliege.be

Description

The Liver Bile Secretion Physiological Map is constructed through the curation of literature evidence and pathway resources. A Physiological Map is a type of Disease Map focused on the underlying undisturbed physiological processes. This work is performed in close collaboration with domain experts. This map is being developed to study chemical-induced cholestasis in the ONTOX project.

References

Ladeira, L., Verhoeven, A., van Ertvelde, J., Jiang, J., Gamba, A., Sanz Serrano, J., Vanhaecke, T., Heusinkveld, H. J., Jover, R., Vinken, M., Geris, L., & Staumont, B. (2024). Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding (1.0). Zenodo. doi: 10.5281/zenodo.14515238

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH. Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology. 2021 Jun 30;458:152846. doi: 10.1016/j.tox.2021.152846. Epub 2021 Jun 30. PMID: 34216698.

Funding

The ONTOX project is funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 963845.