The Inflammatory Skin Disease Map (ISD) pages
Technical information
Development status: Available for exploration online
Online access and exploration: https://imi-biomap.elixir-luxembourg.org
Disease IDs | Psoriasis: DOID:8893, MESH:D011565, MONDO:0005083
Disease IDs | Atopic dermatitis: DOID:3310, MESH:D003876, MONDO:0004980
Sustainable support: LCSB, MINERVA Platform
Construction tool: CellDesigner
Funding: IMI2 BIOMAP No 821511, BIOMAP
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Publication: Preprint
Contact: Marcio Luis Acencio (marcio.acencio(at)gmail.com), Oxana Lopata (oxana.lopata(at)uni.lu) and Marek Ostaszewski (marek.ostaszewski(at).uni.lu), University of Luxembourg
Brief introduction
The ISD map is a network of atopic dermatitis (AD)- and psoriasis (PsO)-specific causal molecular interactions represented as computable diagrams. It is available as a set of interactive diagrams, similar to canonical pathway databases, but focused on AD and PsO mechanisms. The ISD map can be used for data interpretation, hypothesis generation and simulation modelling.
| Access the map | Learn how to navigate and explore the map |
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Structure of the ISD map
The map is comprised by three layers: a side-by-side layer that is the entry point for the ISD map and contains the key molecules and cells associated with AD and PsO, the intercellular communication views depicting how AD and PsO-relevant cell types interact, and the intracellular pathways layer illustrating signalling networks within some selected cells.
AD map
| Intercellular communication layer | Intracellular pathways layer |
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PsO map
| Intercellular communication layer | Intracellular pathways layer |
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Applications of the ISD map
To demonstrate how the map can be used, we offer here some applications along with a step-by-step guide to reproduce the analysis.
Analysis of the network structure
- Discovering possible pathways in KC that counteract the anti-inflammatory effect of dupilumab (Step-by-step guide)
Integration of genetic variation data into the map
- SNPs in upstream IFNG regulators in Th1 cells favor upregulation of IFNG and drive resistance to dupilumab (Step-by-step guide)
- SNPs in upstream apoptosis regulators in psoriatic KCs drive their resistance to cytokine-induced apoptosis. (Step-by-step guide)
Integration of transcriptomics and proteomics data into the map
- IL26 rescues the expression of TSLP, CCL20 and IL33 in AD keratinocytes under dupilumab treatment (Step-by-step guide)