The Inflammatory Skin Disease Map (ISD) pages
Development status: Available for exploration online
Online access and exploration: https://imi-biomap.elixir-luxembourg.org
Disease IDs | Psoriasis: DOID:8893, MESH:D011565, MONDO:0005083
Disease IDs | Atopic dermatitis: DOID:3310, MESH:D003876, MONDO:0004980
Sustainable support: LCSB, MINERVA Platform
Construction tool: CellDesigner
Funding: IMI2 BIOMAP No 821511, BIOMAP
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Publication: Preprint
Contact: Marcio Luis Acencio (marcio.acencio(at)gmail.com), Oxana Lopata (oxana.lopata(at)uni.lu) and Marek Ostaszewski(marek.ostaszewski(at).uni.lu), University of Luxembourg
Brief introduction
The ISD map is a network of atopic dermatitis (AD)- and psoriasis (PsO)-specific causal molecular interactions represented as computable diagrams. It is available as a set of interactive diagrams, similar to canonical pathway databases, but focused on AD and PsO mechanisms. The ISD map can be used for data interpretation, hypothesis generation and simulation modelling.
| Access the map |
Learn how to navigate and explore the map |
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Structure of the ISD map
The map is comprised by three layers: a side-by-side layer that is the entry point for the ISD map and contains the key molecules and cells associated with AD and PsO, the intercellular communication views depicting how AD and PsO-relevant cell types interact, and the intracellular pathways layer illustrating signalling networks within some selected cells.
AD map
| Side-by-side layer |
Intercellular communication layer |
Intracellular pathways layer |
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BLA |
PsO map
| Side-by-side layer |
Intercellular communication layer |
Intracellular pathways layer |
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BLA |
Applications of the ISD map
To demonstrate how the map can be used, we offer here some applications along with a step-by-step guide to reproduce the analysis:
