The Inflammatory Skin Disease Map (ISD) pages
Technical information
Development status: Available for exploration online
Online access and exploration: https://imi-biomap.elixir-luxembourg.org
Disease IDs | Psoriasis: DOID:8893, MESH:D011565, MONDO:0005083
Disease IDs | Atopic dermatitis: DOID:3310, MESH:D003876, MONDO:0004980
Sustainable support: LCSB, MINERVA Platform
Construction tool: CellDesigner
Funding: IMI2 BIOMAP No 821511, BIOMAP
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Publication: Preprimt
Contact: Marcio Luis Acencio (marcio.acencio(at)gmail.com), Oxana Lopata (oxana.lopata(at)uni.lu) and Marek Ostaszewski(marek.ostaszewski(at).uni.lu), University of Luxembourg
Brief introduction
The ISD map is a network of atopic dermatitis (AD)- and psoriasis (PsO)-specific causal molecular interactions represented as computable diagrams. It is available as a set of interactive diagrams, similar to canonical pathway databases, but focused on AD and PsO mechanisms. The map can be explored online via the following link: https://imi-biomap.elixir-luxembourg.org/.
The map is comprised by three layers: a side-by-side layer that is the entry point for the ISD map and contains the key molecules and cells associated with AD and PsO, the intercellular communication views depicting how AD and PsO-relevant cell types interact, and the intracellular pathways layer illustrating signalling networks within some selected cells:
AD: keratinocyte, Th1 cell and Th2 cell.
PsO: keratinocyte, melanocyte, fibroblast, Th17 cell, gamma-delta T cell, neutrophil and myeloid-derived suppressor cell.
You will find below links to other pages containing detailed information about the (1) methods used to build and analyze the map and (2) applications of the map, such as the graphical review of key biological process in atopic dermatitis (AD) and psoriasis (PsO) and hypothesis generation via analysis of the map structure with and without integration of omics data or via Boolean simulations. It is important to notice that we also provide a user guide on how to explore and use the ISD map.