Kidney crystallopathy and tubular necrosis

Nephron Physiological Map

Development status: Active development
Umbrella project: ONTOX project
Disease IDs: D007673, D053040
Synonyms: Nephrolithiasis, kidney cortex necrosis
Sustainable support: Biomechanics Research Unit, MINERVA Platform
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Publication: Manuscript in preparation
Construction tool: CellDesigner
Funding: EU Horizon 2020 ONTOX project (grant agreement No 963845)
Contact: Alessio Gamba, University of Liège, agamba(at)uliege.be

Description

The Nephron Physiological Map is constructed through the curation of literature evidence and pathway resources. A Physiological Map is a type of Disease Map focused on the underlying undisturbed physiological processes. This work is performed in close collaboration with domain experts. This map is developed to study chemical-induced nephrolithiasis (crystallopathy) and tubular necrosis in the ONTOX project.

References

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH. Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology. 2021 Jun 30;458:152846. doi: 10.1016/j.tox.2021.152846. Epub 2021 Jun 30. PMID: 34216698.

Funding

The ONTOX project is funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 963845.