Neural tube closure defects

Neural Tube Closure Physiological Map

Development status: Active development, the first version is complete and published
Umbrella project: ONTOX project
Online access and exploration: https://ontox.elixir-luxembourg.org/minerva…
Disease IDs: D009436, MONDO:0018075
Synonyms: Neural tube defects, spina bifida, anencephaly
Sustainable support: Biomechanics Research Unit, MINERVA Platform
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Publication: Manuscript available for the first version, in preparation for the second version.
Construction tool: CellDesigner
How to cite: Heusinkveld, et al. Reprod. Toxicol. 2021. https://doi.org/10.1016/j.reprotox.2020.09.002
Funding: EU Horizon 2020 ONTOX project (grant agreement No 963845)
Contact: Alessio Gamba, University of Liège, agamba(at)uliege.be

Description

The Neural Tube Closure Physiological Map is constructed through the curation of literature evidence and pathway resources. The current version under development is an update of the work of Heusinkveld et al 2021. A Physiological Map is a type of Disease Map focused on the underlying undisturbed physiological processes. This work is performed in close collaboration with domain experts. This map is being developed to study chemical-induced neural tube closure defects in the ONTOX project.

References

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH. Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology. 2021 Jun 30;458:152846. doi: 10.1016/j.tox.2021.152846. Epub 2021 Jun 30. PMID: 34216698.

Funding

The ONTOX project is funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 963845.