P. aeruginosa infection

Pseudomonas aeruginosa Infection Disease Map - PAIDmap

Development status: Active development
Sustainable support: MINERVA Platform, Biomechanics Research Unit
License: Creative Commons Attribution 4.0 International (CC BY 4.0) License
Construction tool: CellDesigner
How to cite: Messina, et al. biorxiv 2024.DOI: 10.1101/2024.10.17.618881
Contact: Francesco Messina, National Institute for Infectious Diseases “ L. Spallanzani” - IRCCS, mss.francesco1984[at]gmail.com

Description

The Pseudomonas aeruginosa Infection Disease Map (PAIDM) project offers a knowledge repository of molecular mechanisms for severe infection due to bacterial pathogens, like Pseudomonas aeruginosa (PA), which remain a public health concern. It represents the result of a multidisciplinary working group, focused on infectious diseases study. This map assembles molecular interaction diagrams of Reactome pathways, reporting molecular interactions between PA and human host described in the literature. This work is done in close collaboration among INMI “Spallanzani” and the University of Liège.

References

Francesco Messina, Claudia Rotondo, Luiz Ladeira, Michele Properzi, Valentina Dimartino, Benedetta Riccitelli, Bernard Staumont, Giovanni Chillemi, Liesbet Geris, Maria Grazia Bocci, Carla Fontana. Building a model of sepsis: data integration unravels pathogenic mechanisms in severe P. aeruginosa infections. bioRxiv 2024.10.17.618881; doi: https://doi.org/10.1101/2024.10.17.618881

Development Team

• Francesco Messina, PhD
  Bioinformatic Scientist, National Institute for Infectious Diseases “L. Spallanzani” - IRCCS

• Luiz Ladeira, PhD
  Researcher, University of Liège, Belgium

• Claudia Rotondo, PhD
  Early Researcher, National Institute for Infectious Diseases “L. Spallanzani” - IRCCS

• Sara Cosetti
  Fellow at National Institute for Infectious Diseases “L. Spallanzani” - IRCCS, Thesis student at University of Rome Tor Vergata

• Bernard Staumont, PhD
  Researcher, University of Liège, Belgium

• Liesbet Geris, PhD
  Professor and Researcher, University of Liege and KU Leuven, Belgium

• Carla Fontana, PhD
  Head of Lab. Microbiology and BioBank, National Institute for Infectious Diseases “L. Spallanzani” - IRCCS

Funding

“Ricerca Corrente” Linea 1 Project 2a (CF) and ‘5 per 1000–2021’ grant of the Italian Ministry of Health (grant No. 5M-2021-23683787) (FM) by the Italian Ministry of Health.